Structural characterization of two oxadiazolic systems used as spacers for potential angiotensin II receptor antagonists

Abstract

The structures of two oxadiazole derivatives, methyl 2-[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]benzoate ( 1) and methyl 2-[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]benzoate2, used as spacers in the synthesis of new potential non-peptide angiotensin receptor antagonists have been determined by X-ray crystallography. In both compounds π–π interactions were observed between the oxadiazole rings and the phenyl rings of neighboring molecules. In the crystal packing of the oxadiazole 2 two C–H⋯O interactions are present.