Abstract
In humans, the Serine Incorporator 5 (Serinc5) protein acts as an anti-HIV restriction factor, inhibiting the infection of new cells by nascent virion. HIV counteracts this intrinsic immune response by targeting Serinc5 for degradation utilizing its auxiliary protein Nef. The remarkable functionality of Nef is conferred by its ability to target multiple host proteins for degradation. Nef interacts with the host’s clathrin adaptor protein complex 2 (AP2), directing clathrin mediated endocytosis machinery to target many of the host cell’s own anti-HIV lines of defense.
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