Abstract
Gelidium crinale, the red algae belonging to Geliaceae Gelidium, is a traditional edible and industrial alga in China. A sulfated polysaccharide (GNP) is successfully separated from Gelidium crinale by acid extraction and two-step column chromatography. Chemical analysis showed that the molecular weight of GNP was 25.8 kDa and the monosaccharide composition had the highest galactose content and confirmed the presence and content (16.5%) of sulfate by Fourier transform infrared spectroscopy (FT-IR) spectrometry as well as barium chloride-gelatin methods. In addition, the effect of GNP on lipopolysaccharide (LPS)-induced oxidative stress and inflammation in macrophages was also evaluated. The research results showed that GNP had fairly strong scavenging activities on 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical, hydroxyl radical, and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical and had Fe2+-chelating ability in a dose-dependent manner. At the same time, it significantly inhibits the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) and the production of pro-inflammatory cytokines in RAW 264.7 cells induced by LPS through blocking the mitogen-activated protein kinase (MAPK)/nuclear factor kappa beta (NF-κB) signaling pathway. These results indicate that GNP may be a latent component anti-inflammation in pharmaceutical and functional food industries.
Highlights
Seaweeds are a natural source which contain a variety of essential nutrients and meet the needs of therapeutic, pharmaceutical, and nutritional fields
The impurities were removed and the total sugar content was determined, and the content was increased to 75.78%
Yang et al (2019) analyzed the monosaccharide composition of polysaccharide from the red algae Gelidium amansii (GA), and the results showed that the main monosaccharide composition of GHE was galactose (86.0%), fucose (8.3%), and xylose (1.1%)
Summary
Seaweeds are a natural source which contain a variety of essential nutrients and meet the needs of therapeutic, pharmaceutical, and nutritional fields. Speaking, they are divided into three groups, namely, brown algae (Phaeophyceae), green algae (Chlorophyceae), and red algae (Rhodophyceae). They are divided into three groups, namely, brown algae (Phaeophyceae), green algae (Chlorophyceae), and red algae (Rhodophyceae) According to reports, it has a variety of important biologically active compounds, such as lipids, polysaccharides, polyphenols, anthraquinones, steroids, flavonoids, alkaloids, triterpenoids, and cardiac glycosides (Cao et al, 2020). The red algal polysaccharides usually consist of carrageenan cellulose, starch, xylan, and porphyrin.
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