Abstract
Salt formation is a good method of increasing solubility, dissolution rate and consequently the bioavailability of poor soluble acidic or basic drugs [Polymorphism in Pharmaceutical Solids, Drugs and the Pharmaceutical Sciences, Vol. 192, 2nd edn, Informa Healthcare, New York, 2009]. The aim of this study was to obtain and to investigate the structural properties of the compound obtained by solvent drop grinding (SDG) method [Chem. Commun. (Camb.) 20 (2002), 2372–2373] at room temperature starting from the 1:1 molar ratios of ambazone (AMB) and niflumic acid (NIA). The thermal behavior of the obtained compound (AMB · NIA) was investigated by differential scanning calorimetry (DSC) and thermogravimetry (TG), the thermal diffusivity and effusivity parameters were determined by photothermal radiometry (PTR). The structural characterization was performed with X-ray powder diffraction (XRPD) and infrared spectroscopy (FTIR). XRPD data and FTIR spectra demonstrated a new structure for AMB · NIA compound as compared to those of the starting materials.
Highlights
The most active areas of modern solid state chemistry represent the identification and characterization of different crystal forms of the same molecule
The aim of this study was to obtain a salt of ambazone with niflumic acid (AMB · NIA) and to characterize its physical–chemical and structural properties using several investigation methods such as: X-ray diffraction, FTIR spectroscopy and several thermal methods
The X-ray powder diffraction patterns of the AMB, NIA and AMB with NIA are clearly different, from these one can be see that the powder diffraction pattern of AMB · NIA solid form presents different features comparing with both of starting materials, that means a solid form of AMB with NIA was obtained an ambazone niflumate salt
Summary
The most active areas of modern solid state chemistry represent the identification and characterization of different crystal forms (polymorphs, solvates, salts and co-crystals) of the same molecule. The solid form selection process was limited to the free drug or pharmaceutically accepted salts. There are two methods by which solid forms may be prepared: solution-based crystallization and grinding. Mechanical chemical methods [8,9,17,20,22], more commonly and usefully described as grinding, have been employed extensively in the preparation of solid forms. I. Kacso et al / Structural characterization of ambazone salt with niflumic acid. The aim of this study was to obtain a salt of ambazone with niflumic acid (AMB · NIA) and to characterize its physical–chemical and structural properties using several investigation methods such as: X-ray diffraction, FTIR spectroscopy and several thermal methods (differential scanning calorimetry, thermogravimetry and photothermal radiometry)
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