Abstract
Four bioactive glasses (70 SiO2-(20-X) CaO-10 P2O5) containing low concentrations of silver (X Ag2O; where X = 0.5, 1, and 1.5 mol%) were synthesized by the conventional sol-gel method. Physical and structural characterization was realized using Fourier Transform Infrared (FT-IR), Thermogravimetric Analysis (TGA), X-ray Diffraction analysis (XRD), and Scanning Electron Microscopy (SEM-EDX). Acellular bioactivity tests were performed by immersion in the SBF solution. Escherichia coli and Staphylococcus aureus were used to evaluate the antibacterial activity of the prepared Ag-doped bioglasses. While FTIR, DRX, and SEM analysis displayed good acellular bioactivity for all bioactive glasses (Ag–70S), the antibacterial activity confirms well the bactericidal effect of 70S 1Ag and 70S 1.5Ag through total growth inhibition (100%) of the two pathogenic bacteria. It is also important to mention that low silver-doped bioglass nanoparticles (Ag2O ≤ 1.5 mol%) could be a required multifunctional candidate in bone tissue engineering.
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