Structural characterisation of β‐cyclodextrin crosslinked by adipic acid

Abstract

SummaryThis study was conducted to investigate the structural characterisation of β‐cyclodextrin (β‐CD) crosslinked by adipic acid. β‐CD was treated with different concentrations (0%, 5%, 10% and 15%, w/v) of adipic acid. Different instruments, such as scanning electron microsope (SEM), Fourier‐transform infrared (FT‐IR) spectroscopy and 1H and 13C nuclear magnetic resonance (NMR) spectra were used to find out chemical structure in the crosslinked β‐CD. SEM analysis suggested that crosslinking β‐CD with 15% adipic acid changed the original morphology and considerably increased the particle size of the raw material. FT‐IR spectroscopy data showed that an intensive absorption band at 1706 cm−1 was present in the β‐CD samples treated with 10% and 15% adipic acid, indicating a crosslinking between hydroxyl groups of β‐CD and carboxyl groups of adipic acid. NMR spectra revealed that the ester linkages between hydroxyl groups of β‐CD and carboxyl groups of adipic acid were formed after crosslinking of β‐CD with adipic acid.