Abstract
The Zrt-/Irt-like protein (ZIP, SLC39A) transporter family consists of thousands of divalent transition metal importers ubiquitous in all the kingdoms of life. The human genome encodes fourteen ZIPs with distinct physiological functions, which are central players in homeostasis of zinc, iron and manganese and associated with human diseases, including cancers. The plant ZIPs are key for beneficial trace element uptake from soil, but also responsible for toxic metal (such as Cd) accumulation in edible portions.
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