Abstract
ポリアミンは多くの生命現象に関与しており，中でもスペルミン（SPM）は転写活性の調節や有害物質からの細胞の保護など重要な役割を担っているため生物に必須な分子である．本稿では細胞内へのSPMの取り込みの役割を担う輸送体ATP13A2について，クライオ電子顕微鏡法・分子動力学シミュレーションから得られた構造基盤を紹介する．
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