Abstract
The activation mechanism of a voltage-gated K+ channel, described as the upward movement of the voltage-sensors triggering the dilation of the constriction site (activation gate) in its ionic permeation pathway, has been functionally studied but awaits structural demonstration. KV4.2, a Shal-type K+ channel, activated by subthreshold membrane potential and manifesting closed-state inactivation (CSI) machinery, represents an ideal candidate for revealing activation-gate dynamics during channel conformational changes.
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