Abstract
Amygdala (Am) as a part of limbic system of the brain defines such important functions as adaptive behavior of animals, formation of emotions and memory, regulation of endocrine and visceral functions. We worked out, with the help of mathematic modelling of the pattern recognition theory, principles for organization of neurophysiological and neuromorphological studies of Am nuclei, which take into account the existing heterogeneity of its formations and optimize, to a great extent, the protocol for carrying out of such investigations. The given scheme of studies of Am’s structural-functional organization at its highly-informative sections can be used as a guide for precise placement of electrodes’, cannulae’s and microsensors into particular Am nucleus in the brain with the registration not only the nucleus itself, but also its extensions. This information is also important for defining the number of slices covering specific Am nuclei which must be investigated to reveal the physiological role of a particular part of amygdaloid complex.
Highlights
Amygdala (Am) as a part of limbic system of the brain defines such important functions as adaptive behavior of animals, formation of emotions and memory, regulation of endocrine and visceral functions
To achieve both these goals we propose to use highly informative sections of Am to provide mathematically determined objective guideline how to select the most appropriate ones for characterization of a particular amygdaloid nucleus among brain’s series of sections
While studying structural-functional organizations of different brain’s areas a morphologist has to work at series of sections. Quantity of these sections is determined by the size of an investigated object, but even in a brain of rather small laboratorial animals on condition that selective series are made, the number of them will often be more than several dozens
Summary
Amygdala (Am) as a part of limbic system of the brain defines such important functions as adaptive behavior of animals, formation of emotions and memory, regulation of endocrine and visceral functions. The given scheme of studies of Am’s structural-functional organization at its highly-informative sections can be used as a guide for precise placement of electrodes’, cannulae’s and microsensors into particular Am nucleus in the brain with the registration the nucleus itself, and its extensions This information is important for defining the number of slices covering specific Am nuclei which must be investigated to reveal the physiological role of a particular part of amygdaloid complex. It is critical to perform accurate stereotaxic placement of electrodes and microsensors into specific brain area and to provide the morphological control post-experimentally to verify in which structures of Am (or its part) manipulations were targeted To achieve both these goals we propose to use highly informative sections of Am to provide mathematically determined objective guideline how to select the most appropriate ones for characterization of a particular amygdaloid nucleus among brain’s series of sections. The advantages of this approach lie in the fact that it provides the possibility to pass from the intuitive to the strictly scientifically—based methods of an experimental planning, that is critical for such complex structure as Am
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
