Abstract
The protocoatomer hypothesis states that MC proteins were key to the origin of the eukaryotes because they form the scaffold of the multi-protein complexes that they use to manipulate membranes. Despite their common origin, eukaryotic MCs display impressive variations in sequence, structure, architecture, interaction, and cage formation. Using a structural approach, proteins with the MC architecture have been detected in bacteria, in the PVC superphylum and in Bacteroidetes. In one bacterial species, Gemmata obscuriglobus, at least one MC-like protein is in tight interaction with the internal membranes and involved in endocytosis. This represents the first molecular link between a bacterial and the eukaryotic endomembrane systems, suggestive of a possible evolutionary relationship between both systems.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
