Structural and functional multi-platform MRI series of a single human volunteer over more than fifteen years

Simon Duchesne,Pascal Tétreault,Arnaud Boré,Christian Beaulieu,Louis Dieumegarde,Farnaz Farokhian,Olivier Potvin,Jean-Christophe Houde,Maxime Descoteaux,Pierre Bellec,Amanpreet Badhwar,Isabelle Chouinard

doi:10.1038/s41597-019-0262-8

Abstract

We present MRI data from a single human volunteer consisting in over 599 multi-contrast MR images (T1-weighted, T2-weighted, proton density, fluid-attenuated inversion recovery, T2* gradient-echo, diffusion, susceptibility-weighted, arterial-spin labelled, and resting state BOLD functional connectivity imaging) acquired in over 73 sessions on 36 different scanners (13 models, three manufacturers) over the course of 15+ years (cf. Data records). Data included planned data collection acquired within the Consortium pour l’identification précoce de la maladie Alzheimer - Québec (CIMA-Q) and Canadian Consortium on Neurodegeneration in Aging (CCNA) studies, as well as opportunistic data collection from various protocols. These multiple within- and between-centre scans over a substantial time course of a single, cognitively healthy volunteer can be useful to answer a number of methodological questions of interest to the community.

Highlights

Background & SummaryReproducibility is a cornerstone scientific principle, especially so when one is faced with measuring instruments that do not produce absolute quantifiable data such as magnetic resonance imaging (MRI)
There is no geometric phantom is able to approximate with sufficient fidelity the intricacies of living organs, especially in the case of the human brain, nor mimic its physiological characteristics
Our goal was to fill this gap by contributing data from a single human volunteer originating from two settings[9]

Summary

Introduction

Background & SummaryReproducibility is a cornerstone scientific principle, especially so when one is faced with measuring instruments that do not produce absolute quantifiable data such as magnetic resonance imaging (MRI). There is no geometric phantom is able to approximate with sufficient fidelity the intricacies of living organs, especially in the case of the human brain, nor mimic its physiological characteristics. To this end, a number of studies have proposed and are using human volunteer(s) as calibration devices, postulating that the time course for changes in any one of the volunteers’ brain will be of smaller magnitude than the changes being measured; in effect, that these brains can be considered nearly identical to themselves across time (the length of the study) and space (scanners and sites)

Objectives

Findings

Methods