Structural and functional features of the erythroid germ in patients with connective tissue dysplasia

Abstract

Introduction. Connective tissue dysplasia (СTD) is a common condition that affects the function of various components of the body.The aim of the work is to determine the current state of the problem of structural and functional characteristics of erythrocytes in persons with СTD.Materials and methods The authors conducted a search and analysis of works in the scientific electronic library E-library, the Federal Electronic Medical Library of the Ministry of Health of the Russian Federation, the bibliographic database of medical publications Medline using the keywords: erythrocytes, membrane structure, erythrocyte functions, hematopoiesis, erythrocyte life cycle, erythrocyte forms, combined with the terms: connective tissue dysplasia, connective tissue, diagnostic methods, antioxidant protection, lipid peroxidation. Fifty-three sources were selected for the review.Results and Discussion Erythrocytes originate from mesenchymal tissue and have their own structural and functional features in individuals with СTD, namely, a violation of the structure of the submembrane cytoskeleton, a change in the composition and location of phospholipids inside the erythrocyte membrane, leading to a decrease in the plasticity of the blood cell membrane. In addition, the appearance of prehemolytic and degenerative forms of erythrocytes has been detected, which also contributes to a reduction in the life cycle of erythrocytes and a tendency to anemia in people with СTD.Conclusion Individuals with СTD have an increased risk of anemia due to structural and functional features of red blood cells, which may lead to hemolysis, which should be taken into account in the examination and management of patients with СTD.