Structural and functional characterisation of new-onset idiopathic dilated cardiomyopathy, and its response to therapy

Darryl P Leong,Lucas Joerg,Adhiraj Chakrabarty,Rebecca Perry,Carmine G De Pasquale,Mitra Shirazi,Payman Molaee,Joseph B Selvanayagam,Amy Penhall,Nicholas Shipp

doi:10.1186/1532-429x-12-s1-p184

Abstract

Introduction The prevalence of myocardial fibrosis among patients with idiopathic dilated cardiomyopathy (IDCM), as detected by the late-gadolinium cardiac magnetic resonance (LG-CMR) technique, is reported to be 28-42% in highly-selected samples from specialist heart failure clinics. The presence of fibrosis has been demonstrated to predict the incidence of major adverse cardiovascular events. However, as the heart failure duration prior to first CMR imaging in these studies was at least 12 months the prevalence of myocardial fibrosis at presentation is unknown. Moreover, the determinants of the response-to-therapy of newly diagnosed IDCM patients have not been characterised using CMR and advanced echocardiographic techniques.

Highlights

The prevalence of myocardial fibrosis among patients with idiopathic dilated cardiomyopathy (IDCM), as detected by the late-gadolinium cardiac magnetic resonance (LG-CMR) technique, is reported to be 28-42% in highly-selected samples from specialist heart failure clinics
The presence of fibrosis has been demonstrated to predict the incidence of major adverse cardiovascular events
As the heart failure duration prior to first CMR imaging in these studies was at least 12 months the prevalence of myocardial fibrosis at presentation is unknown

Summary

Introduction

The prevalence of myocardial fibrosis among patients with idiopathic dilated cardiomyopathy (IDCM), as detected by the late-gadolinium cardiac magnetic resonance (LG-CMR) technique, is reported to be 28-42% in highly-selected samples from specialist heart failure clinics. The presence of fibrosis has been demonstrated to predict the incidence of major adverse cardiovascular events. As the heart failure duration prior to first CMR imaging in these studies was at least 12 months the prevalence of myocardial fibrosis at presentation is unknown. The determinants of the response-to-therapy of newly diagnosed IDCM patients have not been characterised using CMR and advanced echocardiographic techniques. 1. To determine the prevalence of myocardial fibrosis using the LG-CMR technique among newly diagnosed idiopathic dilated cardiomyopathy IDCM patients presenting to a tertiary hospital setting. 2.To characterise cardiac remodelling and functional changes following medical therapy for IDCM To determine the prevalence of myocardial fibrosis using the LG-CMR technique among newly diagnosed idiopathic dilated cardiomyopathy IDCM patients presenting to a tertiary hospital setting. 2.To characterise cardiac remodelling and functional changes following medical therapy for IDCM

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Conclusion