Abstract
Thiopurine S-methyltransferase (TPMT) catalyzes S-methylation of aromatic and heterocyclic sulfhydryl compounds, including the cytotoxic and immunosuppressive thiopurine medications mercaptopurine, azathioprine and thioguanine. Variations in TPMT activity are an important determinant of the therapeutic and toxicologic effect of these drugs.1 Recently our lab and others have isolated and characterized the human gene encoding TPMT,2 permitting us to study the transcriptional regulation of the gene, by structural and functional analysis of its promoter region.
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