Abstract
The ultra structural changes were studied in Trichophyton tonsurans –a clinical isolate, treated with compound ({ά(2-hydroxy-2methylpropyl)-ω[2-hydroxy-3-methylbut-2-en-1-yl] polymethylene}), isolated from ethyl acetate leaf extract of Caesalpinia bonducella. Compound microscopy studies reveal; on normal SDA medium, the germ tubes grew rapidly; long and regularly branched, and their tips appeared normal. But on SDA medium containing 100, 200 and 300 μg/ml of compound, spherical hyphae or bamboo-like-joint hyphae occurred after 7 days of incubation. Hyphae developing from the abnormally swollen microconidia were spherical or ellipsoid and shorter and thicker than those developing from normal microconidia. Though all the three concentrations of compound caused morphological changes in Trichophyton tonsurans, the most prominent change seen in T. tonsurans treated with 300 μg/ml of compound was characterized by several findings: (i) irregular hyphae with broken cell wall, which was the result of longer exposure time; wavy or shrunken hyphae; (ii) extrusion of cellular materials. However in the control, the hyphae were regular and branched with normal tips.
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