Abstract
ABSTRACTThe ultrastructure of collagen fibers in the dermis of Ehlers‐Danlos syndrome (EDS) has been described in several previous reports. However, discussions of the ultrastructural changes in EDS‐Type II have been infrequent and brief. The behavior of alterative degeneration remains unclear, although there has been one previous report each on EDS‐Type I, Type VI, and Type VII (1, 3, 6). Our ultrastructural studies of EDS‐Type II revealed that bundles of collagen fibers were slightly thinner than in normal human skin, as were the individual collagen fibers also. Two or three serrated collagen fibers (up to 188 nm) were seen within the collagen bundle. The width of these serrated fibers was clearly less than in EDS‐Type I, and these fibers were less frequent than in the severe clinical form of EDS. It could be useful to be able to classify the subtypes of the EDS by structural pattern as well as by clinical appearance.
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