Abstract
Objective: to investigate the impact of VDR and MCP-1 gene polymorphisms on the efficiency of 12-month therapy with strontium ranelate (SR) in women with postmenopausal osteoporosis (OP). Subjects and methods. The investigation enrolled 34 postmenopausal women (mean age 65±8 years), who was diagnosed with OP by lumbar spine and/or proximal femur examinations using a Hologic QDR 4500W X-ray bone densitometer. The gene polymorphisms of VDR (BsmI) and MCP-1 (-2518A/G) were genotyped by polymerase chain reaction, followed by restriction fragment length polymorphism analysis. Results and discussion. The carriers of the BB and Вb genotypes of the VDR gene had a statistically significantly lower increase in the bone mineral density (BMD) of the lumbar spine than those of the homozygous recessive bb genotype (p = 0.024 and p = 0.022, respectively) and the bb genotype and the BB+Bb genotype (p = 0.004), and the carriers of the GА genotype of MCP-1 gene had a statistically significantly lower increase in the BMD of the entire proximal femur than those of the homozygous AA genotype (0.2±2.5% and 4.4±4.4%, respectively; p = 0.004) at 12 months after SR treatment. Conclusion. The findings may suggest that the BB and Bb genotypes of the VDR gene and the GA genotype of the MCP-1 gene may negatively affect the efficacy of SR in patients with OP. However, additional studies on a larger sample of patients, including those with other forms of OP, are required to confirm this assumption.
Highlights
Цель исследования – изучение влияния полиморфизмов генов VDR и МСР-1 на эффективность 12-месячной терапии стронция ранелатом (СР) у женщин с постменопаузальным остеопорозом (ОП)
The investigation enrolled 34 postmenopausal women, who was diagnosed with OP by lumbar spine and/or proximal femur examinations using a Hologic QDR 4500W X-ray bone densitometer
The findings may suggest that the BB and Bb genotypes of the VDR gene and the GA genotype of the MCP-1 gene may negatively affect the efficacy of strontium ranelate (SR) in patients with OP
Summary
Стронция ранелат в лечении постменопаузального остеопороза: эффект влияния полиморфизмов генов рецептора витамина D и моноцитарного хемоаттрактантного белка 1 на минеральную плотность кости (пилотное исследование). Цель исследования – изучение влияния полиморфизмов генов VDR и МСР-1 на эффективность 12-месячной терапии стронция ранелатом (СР) у женщин с постменопаузальным остеопорозом (ОП). GENE POLYMORPHISMS ON BONE MINERAL DENSITY: A PILOT STUDY Krylov M.Yu., Nikitinskaya O.A., Samarkina E.Yu., Toroptsova N.V. Objective: to investigate the impact of VDR and MCP-1 gene polymorphisms on the efficiency of 12-month therapy with strontium ranelate (SR) in women with postmenopausal osteoporosis (OP). Например, при изучении сайта PubMed нам встретилась только одна работа, в которой изучалось влияние полиморфизмов генов, участвующих в процессах ремоделирования костной ткани, на динамику МПК на фоне лечения СР [10]. Целью настоящего исследования являлось изучение влияния полиморфизмов генов VDR и МСР-1 на эффективность 12-месячной терапии СР у женщин с постменопаузальным ОП
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