Abstract
BackgroundStent implantation into atherosclerotic coronary arteries releases particulate debris and soluble substances which contribute to impaired microvascular perfusion.MethodsUsing a distal protection/aspiration device, arterial blood was retrieved during stent implantation in 19 patients with a stenosis in native coronary arteries (NA) and in 20 patients with a saphenous vein graft (SVG) stenosis. The constrictor response of rat coronary and mesenteric arteries to aspirate was quantified in a myograph as isometric force development (mN).ResultsAt 80 mmHg, the diameter was 250±28 μm for coronary and 186±16 μm for mesenteric arteries. The KCl (120mM) ‐ induced maximal vasoconstriction was comparable for coronary and mesenteric arteries (6.1±2.3 mN vs. 7.1±1.4 mN; NS). The vasoconstriction provoked by aspirate was greater in coronary than in mesenteric arteries. Aspirate released during stent implantation into NA induced a stronger vasoconstriction than that into SVG (coronary: NA 6.9±0.8*†, SVG 5.2±0.7†, mesenteric: NA 5.6±0.9*, SVG 4.2±0.5 mN; *p<0.05 NA vs. SVG, †p<0.05 coronary vs. mesenteric arteries).ConclusionHuman coronary aspirate released during stenting of NA has a stronger vasoconstrictor potential than that from SVG. The vasoconstrictor response to human coronary aspirate is more profound in rat coronary than in mesenteric arteries.
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