Abstract
Background African green monkeys (AGMs), natural SIV hosts, sustain nonpathogenic infections and rarely transmit the virus to their suckling infants, despite exposure to high milk virus RNA loads. Furthermore, we previously reported strong autologous neutralization responses in milk of SIV-infected AGMs which could contribute to impediment of infant virus acquisition. Comparing mucosal B cell populations and responses in milk of AGMs to that of rhesus monkeys (RMs), symptomatic SIV hosts with high rates of postnatal transmission, could elucidate the protection against postnatal virus transmission in natural SIV hosts. Methods
Highlights
African green monkeys (AGMs), natural SIV hosts, sustain nonpathogenic infections and rarely transmit the virus to their suckling infants, despite exposure to high milk virus RNA loads
Strong SIV gp120-specific IgG/IgA responses in milk of African green monkeys may contribute to the rarity of postnatal transmission in this species
We previously reported strong autologous neutralization responses in milk of SIV-infected AGMs which could contribute to impediment of infant virus acquisition
Summary
African green monkeys (AGMs), natural SIV hosts, sustain nonpathogenic infections and rarely transmit the virus to their suckling infants, despite exposure to high milk virus RNA loads. We previously reported strong autologous neutralization responses in milk of SIV-infected AGMs which could contribute to impediment of infant virus acquisition. Comparing mucosal B cell populations and responses in milk of AGMs to that of rhesus monkeys (RMs), symptomatic SIV hosts with high rates of postnatal transmission, could elucidate the protection against postnatal virus transmission in natural SIV hosts
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
