Abstract
Cardiac troponin T (cTnT) and I (cTnI), measured with high-sensitive assays, are the preferred biomarkers for the diagnosis of acute myocardial infarction [ 1 Roffi M. Patrono C. Collet J.P. Mueller C. Valgimigli M. Andreotti F. et al. 2015 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: Task Force for the Management of Acute Coronary Syndromes in Patients Presenting without Persistent ST-Segment Elevation of the European Society of Cardiology (ESC). Eur. Heart J. 2016; 37: 267-315 Crossref PubMed Scopus (4337) Google Scholar , 2 Mills N.L. Churchhouse A.M. Lee K.K. Anand A. Gamble D. Shah A.S. et al. Implementation of a sensitive troponin I assay and risk of recurrent myocardial infarction and death in patients with suspected acute coronary syndrome. JAMA. 2011; 305: 1210-1216 Crossref PubMed Scopus (271) Google Scholar ]. Serial cardiac troponin measurements, and the interpretation of a “troponin rise-or-fall” in patients with chest pain discriminate between acute and chronic troponin elevations [ [1] Roffi M. Patrono C. Collet J.P. Mueller C. Valgimigli M. Andreotti F. et al. 2015 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: Task Force for the Management of Acute Coronary Syndromes in Patients Presenting without Persistent ST-Segment Elevation of the European Society of Cardiology (ESC). Eur. Heart J. 2016; 37: 267-315 Crossref PubMed Scopus (4337) Google Scholar ]. This diagnostic concept assumes that troponin levels in patients without acute cardiac injury fluctuate randomly around an individual's homeostatic setpoint. However, it has recently been demonstrated that cTnT exhibits a diurnal rhythm [ 3 Klinkenberg L.J. van Dijk J.W. Tan F.E. van Loon L.J. van Dieijen-Visser M.P. Meex S.J. Circulating cardiac troponin T exhibits a diurnal rhythm. J. Am. Coll. Cardiol. 2014; 63: 1788-1795 Abstract Full Text Full Text PDF PubMed Scopus (65) Google Scholar , 4 Aakre K.M. Roraas T. Petersen P.H. Svarstad E. Sellevoll H. Skadberg O. et al. Weekly and 90-minute biological variations in cardiac troponin T and cardiac troponin I in hemodialysis patients and healthy controls. Clin. Chem. 2014; 60: 838-847 Crossref PubMed Scopus (75) Google Scholar ]. The amplitude of the diurnal cTnT rhythm and its diagnostic implication in patients with chronically elevated cTnT levels are unexplored. Also, whether cTnT and cTnI are equally affected by rhythmic diurnal oscillation is unknown.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
