Abstract
Background and Aims: Fibroblast growth factor 21 (FGF21) is a hormonal regulator of lipid and glucose metabolism exerting protection against atherosclerosis by multiple actions on the blood vessels, liver, and adipose tissues. Enhanced FGF21 production in diabetes and obesity reduces the level of LDL-C and triglycerides by suppression of hepatic SREBP-2. Hypothyroidism has also been shown to have unfavorable effects on atherogenesis and dyslipidemia. To date, the association of lipid parameters and FGF21 levels in autoimmune thyroiditis has not been studied.
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