Abstract
The purpose of this study was to analyze the correlation between renal function and subfoveal choroidal thickness (SFChT) in treatment-naïve proliferative diabetic retinopathy (PDR) patients. This study included 85 eyes of 52 treatment-naïve PDR patients who underwent kidney function testing and urinalysis and 42 eyes of 33 age-matched controls. Treatment-naïve eyes with PDR were categorized into pachychoroid and leptochoroid groups based on the SFChT of the control group. Kidney function profiles were compared between pachychoroid and leptochoroid groups; the relationship between kidney function profile and SFChT was evaluated using regression analysis. Compared with the pachychoroid group, the leptochoroid group had significantly higher serum creatinine (p = 0.026), cystatin C (p = 0.004), and phosphorus (p < 0.001) levels and a lower estimated glomerular filtration rate (eGFR) (p < 0.001). Multivariate linear regression analyses showed that SFChT was positively correlated with eGFR (Cystatin C) (p = 0.007) and negatively correlated with serum phosphorus (p = 0.001). SFChT of patients with eGFR < 30 mL/min/1.73 m2 and serum phosphorus level ≥4.0 mg/dL was less than that of patients with higher eGFR and lower serum phosphorus level. The choroidal thickness of treatment-naïve PDR patients is closely affected by renal function. Kidney function test should be considered if SFChT of patients with treatment-naïve PDR is reduced.
Highlights
Diabetic retinopathy (DR) is a major cause of visual deterioration worldwide and is estimated to affect up to 35% of diabetes patients [1]
There were no significant differences in age, body mass index (BMI), refractive error, and IOP between the two groups
We investigated the correlation between renal function and choroidal thickness (ChT) of the eyes of treatment-naïve proliferative diabetic retinopathy (PDR) patients
Summary
Diabetic retinopathy (DR) is a major cause of visual deterioration worldwide and is estimated to affect up to 35% of diabetes patients [1]. The choroid is a highly vascularized layer that surrounds and supports the retina, [2] and it plays an important role in the pathogenesis of DR; abnormalities in choroidal vasculature may be responsible for visual impairment in eyes with DR [3]. SS-OCT uses longer wavelengths and faster scanning speed lasers, which allow for deep range imaging and increased averaging [6]. Using these techniques, several studies have revealed the relationship between choroidal thickness (ChT) and various systemic factors such as age, sex, and hormonal change or diseases, including systemic hypertension or cardiovascular disease, systemic inflammatory conditions, hematological diseases, and neurological diseases [7]. The choroid can be affected by these systemic conditions because it is a highly vascular tissue with the highest level of blood flow in the body [8]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
