Abstract
Chromosomal aberrations (CAs) in blood lymphocytes have been shown to be associated with overall cancer risk and aging. However, their relationship to bladder cancer risk remains to be elucidated. In a case-control study of bladder cancer in Egypt, we examined the relationship between the increased frequency of CAs in blood lymphocytes and bladder cancer risk. High frequency of CAs was significantly associated with an increased risk of bladder cancer [adjusted odds ratios (OR) = 3.90, 95% confidence interval (CI) = 2.65–5.73]. The associations were somewhat stronger in squamous cell carcinomas (SCC, OR = 4.90) than in urothelial carcinomas (UC, OR = 3.62). We also identified chromosome specific CAs for chromosomes 3, 4, 5, 8, 9, 10, 11, 12, 17, 19 that were significantly associated with an increased risk of bladder cancer. We observed particularly strong associations between aberrations of chromosomes 12, 13, 17 and risk of SCC (OR = 7.06, 6.91 and 6.23, respectively). Conclusion: increased frequency of chromosomal aberrations in blood lymphocytes was significantly associated with bladder cancer risk. Overall and chromosome specific aberrations in blood lymphocytes may be a unique set of biomarkers for risk assessments of SCC and UC.
Highlights
Chromosomal aberrations (CAs) in blood lymphocytes have been shown to be associated with overall cancer risk and aging
We showed that a high frequency of blood lymphocytes with structural CAs is significantly associated with an increased risk of bladder cancer and that the risk association is slightly stronger in squamous cell carcinoma (SCC) than in urothelial carcinoma (UC)
Our results are consistent with findings from previous cohort studies which showed that CA frequency in blood lymphocytes was significantly associated with risk of multiple cancers of other organ sites[8,9,10,13,14,15,16]
Summary
Chromosomal aberrations (CAs) in blood lymphocytes have been shown to be associated with overall cancer risk and aging. Their relationship to bladder cancer risk remains to be elucidated. Conclusion: increased frequency of chromosomal aberrations in blood lymphocytes was significantly associated with bladder cancer risk. We examined the association between the frequency of CAs in blood lymphocytes and bladder cancer risk in a large case-control study that included sufficient numbers of both UC and SCC patients to examine the two subtypes of cancer separately (533 cases and 560 controls). The large sample size allowed us to examine the associations between chromosome specific CAs in blood lymphocytes and bladder cancer risk for the first time
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