Abstract
A new hydrophilic polymeric nanocomposite containing AgNPs was synthesized by chemical reduction of metal ions in an aqueous medium in the presence of the copolymer. A new water-soluble copolymer of 1-vinyl-1,2,4-triazole and vinylsulfonic acid sodium salt (poly(VT-co-Na-VSA)) was obtained by free-radical copolymerization and was used as a stabilizing precursor agent. The structural, dimensional, and morphological properties of the nanocomposite were studied by UV–Vis, FTIR, X-ray diffraction, atomic absorption, transmission and scanning electron microscopy, dynamic and electrophoretic light scattering, gel permeation chromatography, thermogravimetric analysis, and differential scanning calorimetry. Hydrodynamic diameter of macroclubs for the copolymer was 171 nm, and for the nanocomposite it was 694 nm. Zeta potential for the copolymer was −63.8 mV, and for the nanocomposite it was −70.4 mV. The nanocomposite had strong antimicrobial activity towards Gram-negative and Gram-positive microorganisms: MIC and MBC values were in the range of 0.25–4.0 and 0.5–8.0 μg/mL, respectively.
Highlights
Accepted: 13 January 2022Nanocomposites containing silver nanoparticles (AgNPs) exhibit effective antimicrobial activity and cytotoxic properties and are widely used in biomedicine [1,2,3,4,5,6]
Structure and composition of the copolymer were established by elemental analysis data, Fourier transform infrared (FTIR), 1 H NMR spectroscopy, SEM microscopy, gel permeation chromatography (GPC), and light scattering measurements
Differential Scanning Calorimetry be noted that the thermal stability of the nanocomposite is 15 ◦ C lower than that of the According to thermogravimetric analysis and differential scanning calorimetry initial copolymer poly(VT-co-Na-VSA), which is due to the catalytic features of Accepted: January 2022Nanocomposites containing silver nanoparticles (AgNPs), (DSC) data, the resulting nanocomposite is characterized by heat resistance to oxidative leading to a decrease in the activation energy of thermal destruction and oxidation of the degradation up to 305 °C (Figure 9)
Summary
Nanocomposites containing silver nanoparticles (AgNPs) exhibit effective antimicrobial activity and cytotoxic properties and are widely used in biomedicine [1,2,3,4,5,6]. Various methods for reducing silver ions and stabilizing the obtained particles are intensively studied Various polymers, both synthetic (polystyrene, polyvinylpyrrolidone, polyethylene glycol, polyacrylamide, polyvinyltriazole, etc.) and natural (cellulose, gelatin, etc.) exhibit high stabilizing activity in the formation of AgNPs [15,19,20,21,22,23,24,25,26,27,28,29,30,31,32]. Along with the synthesis of a new copolymer of 1-vinyl-1,2,4-triazole with the sodium salt of vinyl sulfonic acid, we discuss the features of the formation of a new hydrophilic silver-containing nanocomposite based on it. We discuss the results of the study of the main physicochemical, structural, optical, and thermal properties of the copolymer and nanocomposite, as well as their antimicrobial activity against various strains of Gramnegative and Gram-positive microorganisms
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