Abstract

• Protic acid-catalyzed synthesis of functionalized trans -disubstituted tetrahydrofurans. • Electrophilic ring expansion reaction of sulfoxonium ylides to oxetanes was developed. • A transition metal-free ring expansion reaction of oxetanes to tetrahydrofurans. • Ring expansion of oxetanes to tetrahydrofurans with safe and stable ylides. • Stereospecific synthesis of functionalized trans -2,3-disubstituted tetrahydrofurans. A strong protic acid-catalyzed electrophilic ring expansion of oxetanes into trans -2,3-disubstituted tetrahydrofuran derivatives using sulfoxonium ylides has been developed. This reaction produces functionalized trans -2,3-disubstituted tetrahydrofuran derivatives stereospecifically by using safe and stable sulfoxonium ylides without metal catalysts and the protection of inert gas.

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