Abstract
Objective: To study the associations of stromelysin-1 (MMP3) gene 5A/6A polymorphism with plasma high-sensitivity C-reactive protein (hs-CRP) level in coronary artery disease (CAD) and myocardial infarction (MI). Methods: The MMP3 5A/6A genotypes and plasma hs-CRP levels were determined in 405 non-CAD subjects and 395 angiography-documented CAD patients, 157 with MI and 238 with non-MI. Results: The percentage of the 5A/5A genotype was significantly (p < 0.001) greater in CAD than non-CAD subjects and in MI than non-MI patients. Plasma hs-CRP level of the 5A/5A genotype was significantly (p < 0.05) higher than that of the 6A/6A genotype in CAD and MI but not in non-MI patients. On logistic regression analysis, the odds ratio of the 5A/5A genotype for CAD was 2.11 (95% CI, 1.15 - 3.88, p < 0.05) and for MI was 3.05 (95% CI, 1.54 - 6.04, p < 0.005). Conclusions: This study showed a correlation of the 5A/5A genotype of MMP3 promoter with higher plasma hs-CRP level in CAD patients with MI.
Highlights
Rupture of atherosclerotic plaque plays a critical role in acute coronary syndrome (ACS) and myocardial infarctionHow to cite this paper: Jeng, J.-R. (2016) Stromelysin-1 Gene Promoter 5A/6A Polymorphism and Plasma C-Reactive Protein in Patients with Coronary Artery Disease and Myocardial Infarction
Ye et al [3] identified a common polymorphism in the promoter of MMP3 gene, located 1171 bp upstream from the transcription, with one allele having a run of six adenosines (6A) and the other having five adenosines (5A)
The 5A/5A genotype percentage of MMP3 was significantly greater in coronary artery disease (CAD) patients than non-CAD subjects (13.2% vs. 8.4%, p < 0.001), but the 5A allele frequency was not (0.239 vs. 0.274)
Summary
Rupture of atherosclerotic plaque plays a critical role in acute coronary syndrome (ACS) and myocardial infarctionHow to cite this paper: Jeng, J.-R. (2016) Stromelysin-1 Gene Promoter 5A/6A Polymorphism and Plasma C-Reactive Protein in Patients with Coronary Artery Disease and Myocardial Infarction. Rupture of atherosclerotic plaque plays a critical role in acute coronary syndrome (ACS) and myocardial infarction. (2016) Stromelysin-1 Gene Promoter 5A/6A Polymorphism and Plasma C-Reactive Protein in Patients with Coronary Artery Disease and Myocardial Infarction. Jeng (MI) in patients with coronary artery disease (CAD) [1]. Stromelysin-1 (MMP3) may be involved in plaque rupture because it can cleave the extracellular matrix (ECM) proteins [2]. In the meta-analysis studies [6]-[8], the 5A allele was associated with acute MI [6] [7], and the effect of the 5A/6A genotypes on CAD risk was ethnicity-specific and more prominent for MI patients or East Asians [8]. Xu et al [9] further reported that the 5A/5A genotype was associated with a risk for ACS in the Chinese
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