Abstract
Objective: To analyze podoplanin (PDPN) and Twist stromal immunoexpression profiles in a series of oral tongue squamous cell carcinoma (OTSCC) and lower lip squamous cell carcinoma (LLSCC) cases and evaluate their relationship with clinical-pathologic parameters. Study Design: PDPN and Twist immunoexpression were qualitatively evaluated by analyzing stromal fibroblast staining. The statistical associations and correlations with clinicopathologic characteristics were verified by the Mann-Whitney and Spearman tests. Results: In LLSCC, the male-to-female ratio was 3:1 with a mean age ± standard deviation (SD) of 66.8 ± 15.1 years, with the seventh decade being the most affected age group. In OTSCC, the male-to-female ratio was 3:1, with a mean age ± SD of 61.0 ± 12.7 years, with the sixth decade being the most affected age group. Regarding the clinical parameters in both lesions, there were no statistically significant results for PDPN; for Twist, stromal immunoexpression was statistically significant for cases in the earliest stages (I and II). In the Spearman test, a significant positive correlation was observed only in LLSCC cases (P
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