Strok alt gruplarında lenfosit monosit oranındaki değişimin değerlendirilmesi

Abstract

Abstract Backround: Stroke is one of the most important disease causing serious morbidity and mortality worldwide. There are some studies showing the change in hematological inflammatory markers in stroke patients. Lymphocyte to monocyte ratio (LMR) is considered to be a new hematological inflammatory marker that has been recently investigated in many malignancies with its particularly low level. In this study, we aimed to evaluate the levels of LMR in patients presented to our emergency department with neurological findings, diagnosed as ischemic stroke and also we aimed to evaluate the levels of LMR in subgroups according to the Oxfordshire Community Stroke Project (OCSP) classification which is a clinical classification. Material and Methods: The patients admitted to the emergency department of a university hospital with symptoms of neurological disorders and diagnosed with ischemic stroke between January 2017 and January 2019 were retrospectively analyzed. Stroke patients were divided into subgroups according to OCSP classification and clinical and imaging results were correlated. Hematologic inflammatory markers were examined in all groups and changes in LMR were detected. Results: 109 (63 female, 46 male) ischemic stroke patients and 110 (45 female, 65 male) control patients were included in the study. The low LMR values were found to be statistically significant in stroke cases compared to the control group (p <0.05). The low LMR values were found to be statistically significant in all four subgroups compared to the control group (p <0.05). TACI and POCI groups showed the lowest mean in LMR values. Higher NLR and GGT values were found to be statistically significant in all four groups compared to the control group (p <0.05). Conclusion: In our study, the LMR value, which was limited investigated in stroke subgroups, was found to be low in all stroke and subgroups. Especially in clinical situations with large infarct sizes such as TACI and POCI groups, the lowest means were reached. It is thought that LMR can be used as a predictor of mortality, morbidity, and prognosis in both stroke and its subgroups.