Abstract
AbstractStrigolactones are a class of carotenoid‐derived plant hormones, which impact many functions of plant metabolism in response to environmental stress. They also act as exogenous signals perceived by both mycorrhizal fungi and parasitic plants. The peculiar chemical skeleton of these molecules and their mode of action in plants inspired possible applications in biomedical fields. In this minireview, an overview of the most recent applications of Strigolactones and analog derivatives as anticancer, anti‐inflammatory, and antiviral drugs is described.
Highlights
Strigolactones (SLs) are a class of carotenoid-derived molecules
In 2005 it was reported that the release of SLs by plant roots stimulates the hyphal branching in arbuscular mycorrhizal (AM) fungi and enhances the efficiency of symbiosis.[4]
Natural SLs have complex structures with a core composed of a tricyclic ABC lactone ring system which is linked to a butenolide D-ring by an enol-ether bridge (Figure 1).[9]
Summary
Strigolactones (SLs) are a class of carotenoid-derived molecules Since their first isolation in 1966 as promoting agents for the germination of root parasitic Striga plants,[1] diverse endogenous plant functions have been described for SLs in the control of shoot and root branching, fruit ripening, secondary growth, senescence, stress response,[2] biotic and abiotic stress resistance.[3] These new bio properties give rise to recognition of SLs as novel phytohormones. Processes.[6] Phytohormones with therapeutic activity can be exploited for cancer treatment as well as for their antiinflammatory and antiviral activity mainly because they are biocompatible and have well-characterized functions.[7] Owing to their new bio properties and the high potential of applications of SLs in the biomedical field there is a strong stimulus in the discovery of structurally related either natural or synthetic compounds with SL- like activity. At least 25 naturally occurring SLs have been identified and characterized.[8]
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