Striatopallidal NMDA-receptors control locomotor and conditioning behaviours.

Abstract

Event Abstract Back to Event Striatopallidal NMDA-receptors control locomotor and conditioning behaviours. Laurie Lambot1*, Elena Chaves Rodriguez1, Yuqing Li2, Serge N. Schiffmann1, Alban De Kerchove D’Exaerde1 and David Gall1 1 Université Libre de Bruxelles, Faculté de Médecine, Belgium 2 University of Florida, College of Medicine, Department of Neurology, United States The basal ganglia (BG) are composed of several interconnected nuclei that have a critical role in goal-directed action selection, motor control, and habits. The striatum, the major input site of the BG, is predominantly composed of medium spiny neurons (MSN), which give rise to two projection circuits originating from two distinct populations of MSN: the striatonigral MSN (dMSN) give rise to the direct pathway and the striatopallidal MSN (iMSN) to the indirect pathway. Balanced activity between both pathways is crucial for harmonious functions of the BG. Imbalance of those two neuronal subpopulations is implicated in major neuropsychiatric disorders such as Parkinson and Huntington diseases as well as drug addiction. Despite the increasing knowledge concerning the key role of the striatal glutamate NMDA receptor (NMDA-R) for the BG physiology, it is still challenging to understand the specific functions of striatopallidal neuron NMDA-R. In this study, by a conditional deletion of the essential GluN1 subunit of NMDA-R specificaly in striatopallidal neurons (cKO), the functions of the NMDA-R in the indirect pathway were adressed. At the cellular level, the deletion of GluN1 in iMSN leads to the reduced number and strength of the excitatory corticostriatopalidal synapses and the intrinsic electro-responsiveness of the iMSN was higher, reflecting an homeostatic adaptation partially compensating the reduced synaptic inputs. The behavioral consequence of the NMDA-R absence in iMSN is an aberrant action selection in goal directed behaviour, without alteration of motor learning but changing of motor strategy, as well as alteration in habituation and amphetamine locomotor sensitization. Taken together, these data indicate that the loss of NMDA-R in the striatopallidal neurons disrupts operant and habituation behaviours. Acknowledgements L.L. was supported by a FRIA (Fonds pour la formation à la Recherche dans l'Industrie et dans l'Agriculture) PhD fellowship from the Fund for Scientific Research-Fonds de la Recherche Scientifique (FRS-FNRS) (Belgium) and Van Buuren grant from the fonds David et Alice Van Buuren. This study was supported by the Fondation Médicale Reine Elisabeth (Belgium). We would like to acknowledge Dr Frédéric Bollet-Quivogne of the Light Microscopy Facility (LiMiF). Keywords: NMDA receptor, Neuronal morphology, Striatum, goal-directed behavior, Synaptic Transmission Conference: 11th National Congress of the Belgian Society for Neuroscience, Mons, Belgium, 22 May - 22 May, 2015. Presentation Type: Oral or Poster presentation Topic: Neuroscience Citation: Lambot L, Chaves Rodriguez E, Li Y, Schiffmann SN, De Kerchove D’Exaerde A and Gall D (2015). Striatopallidal NMDA-receptors control locomotor and conditioning behaviours.. Front. Neurosci. Conference Abstract: 11th National Congress of the Belgian Society for Neuroscience. doi: 10.3389/conf.fnins.2015.89.00074 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 30 Apr 2015; Published Online: 05 May 2015. * Correspondence: Miss. Laurie Lambot, Université Libre de Bruxelles, Faculté de Médecine, Bruxelles, 1070, Belgium, laurie.s.lambot@gmail.com Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Laurie Lambot Elena Chaves Rodriguez Yuqing Li Serge N Schiffmann Alban De Kerchove D’Exaerde David Gall Google Laurie Lambot Elena Chaves Rodriguez Yuqing Li Serge N Schiffmann Alban De Kerchove D’Exaerde David Gall Google Scholar Laurie Lambot Elena Chaves Rodriguez Yuqing Li Serge N Schiffmann Alban De Kerchove D’Exaerde David Gall PubMed Laurie Lambot Elena Chaves Rodriguez Yuqing Li Serge N Schiffmann Alban De Kerchove D’Exaerde David Gall Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.