Abstract
Striatal D 1 dopamine (DA) antagonist binding sites were investigated in intact female and male rats, ovariectomized (OVX) animals and during the 4-day estrous cycle. The affinity of the striatal D 1 receptor as labelled with [ 3H]SCH 23390 remains unchanged in intact male, female rats during the estrous cycle and OVX animals. By contrast, ovariectomy decreased striatal D 1 receptor density by 17% ( P < 0.01) compared to intact female rats while a small but significant higher density was observed in intact male compared to female rats (10% higher, P < 0.05). The density of striatal D 1 DA receptor was higher on the day of diestrus I (DI) and diestrus II (DII) ( P < 0.01 vs OVX) and fluctuates throughout the estrous cycle with a maximum on the day of DII ( P < 0.05 vs proestrus PM). Our results show for the first time that striatal D 1 DA receptors fluctuate during the estrous cycle and can be modulated by gonadal steroids.
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