Abstract
Bioelectronics The cyborg brain organoid platform reported by Jia Liu and co-workers in article number 2106829 features “tissue-like” stretchable mesh nanoelectronics designed to match the mechanical properties of brain organoids and to be folded by the organogenetic process of progenitor or stem cells. Long-term stable, continuous recording is enabled and the emergence of single-cell action potentials from early-stage brain organoid development can be captured. A 3D reconstructed fluorescence image of cyborg brain organoid tissue is shown. The red represents neural stem cells, the green neurons, the blue cell nuclei, and the yellow soft nanoelectronic interconnects and sensors.
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