Abstract
Stressing out the ER in aminoglycoside-induced hearing loss.
Highlights
Aminoglycoside antibiotics are widely used in the treatment of a variety of bacterial infections.[1]
endoplasmic reticulum (ER) stress engages an adaptive reaction to restore proteostasis known as the unfolded protein response (UPR)
Under conditions of chronic or irreversible ER stress, the UPR induces apoptosis through distinct overlapping signaling mechanisms, which include the upregulation of the transcription factor CHOP, the induction of oxidative stress, and the engagement of classical mitochondrial apoptosis pathway.[9]
Summary
Aminoglycoside antibiotics are widely used in the treatment of a variety of bacterial infections.[1]. Despite the fact that protein-folding stress is a hallmark of the most common diseases affecting the nervous system,[6] its contribution to ototoxicity remained unknown.
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