Stress-Induced Colibacillosis and Turkey Osteomyelitis Complex in Turkeys Selected for Increased Body Weight

Abstract

Two stress models were used to induce colibacillosis and turkey osteomyelitis complex (TOC): Escherichia coli challenge following dexamethasone injection (Dex) and E. coli challenge preceding transport stress (Transport). A total of 160 birds from 3 lines of turkeys: a slow-growing line selected for egg production (Egg), a line selected for 16-wk BW (F line), and a Commercial line (Comm), were studied in a 3 × 3 × 2 (line × treatment × sex) factorial design. At 14 wk, the Dex group was treated with 3 injections of 2 mg of Dex/kg of BW followed by airsac challenge with 100 cfu of E. coli. The Transport group was given 5,000 cfu of the same E. coli and 8 d later was transported for 3 h and held for an additional 9 h in the transport vehicle. Controls of each line were neither stressed nor challenged with E. coli. Birds were necropsied 2 wk postchallenge. All birds were sexed, scored for airsacculitis (AS) and TOC, and knee synovia were cultured for E. coli. Percent mortality was unaffected by sex, was increased by the Dex treatment, and was higher in Dex-treated male Comm-line birds and Dex-treated female F-line birds compared with their respective nonchallenged controls. Both treatments increased AS scores, and scores of Dex-treated male Comm-line birds and female F-line birds were also higher compared with their respective controls. Male Comm birds under Transport had higher AS scores as compared with nonchallenged males and challenged females. The TOC incidence was increased by Dex only. There was no TOC in Egg-line birds, whereas TOC incidence approached significance in both Comm and F lines compared with the Egg line (P = 0.06). Males had twice as much TOC as females, and this approached significance in the F line (P = 0.06). There was a low level of TOC in male Transport birds of both large-bodied lines, whereas no female Transport birds had TOC lesions. Dex-treated male birds of both the F line and Comm line had significantly higher incidence of TOC compared with their respective nonchallenged controls. The challenge strain of E. coli was isolated from more knee cultures of both large lines compared with the Egg line. Isolation was increased by Dex and was higher in male Comm-line birds and both male and female F-line birds relative to their controls. The difference in disease resistance between these lines suggests that selection for fast growth of turkeys may affect the stress response, resulting in increased chronic bacterial disease such as TOC.