Abstract
OBJECTIVESElevated serum triglyceride levels are a risk factor for developing cardiovascular disease. A number of studies have demonstrated a positive association between psychological stress and serum triglyceride levels. However, there is limited evidence regarding the impact of stressful life events (SLEs) on serum triglyceride levels in the healthy population. Therefore, we evaluated the independent association between SLEs and serum triglyceride levels in a middle-aged Korean population.METHODSWe analyzed a sample of 2,963 people (aged 30-64 years; 36% men) using baseline data from the Cardiovascular and Metabolic Diseases Etiology Research Center (CMERC) cohort study. The Korean version of the Life Experience Survey questionnaire was used to measure the presence and positive/negative impact of SLEs. Hypertriglyceridemia was defined as a fasting serum triglyceride level of ≥ 150 mg/dL.RESULTSOf the 2,963 participants, 33.1% reported at least 1 SLE over the past 6 months and 24.8% had hypertriglyceridemia. Even after adjusting for potential confounders, the serum triglyceride level was significantly associated with the total number of SLEs in men (3.333 mg/dL per event; p= 0.001), but not in women (0.451 mg/dL per event, p= 0.338). Hypertriglyceridemia was also associated with having 4 or more SLEs with positive effects (odds ratio [OR], 2.57; 95% CI, 1.02 to 6.46) and 4 or more SLEs with negative effects (OR, 1.99; 95% CI, 1.16 to 3.41) in men.CONCLUSIONSOur findings suggest that SLEs may increase the risk of hypertriglyceridemia in middle-aged men.
Highlights
An elevated serum triglyceride level is a risk factor for developing cardiovascular disease
There is limited evidence regarding the impact of stressful life events (SLEs) on the serum triglyceride levels among the healthy population
We evaluated the independent association between stressful life events (SLEs) and serum triglyceride levels in a middle-aged t Korean population. in Methods: pr We conducted this study using a sample of 2963 people of using baseline data from the Cardiovascular and Metabolic diseases Etiology Research d Center (CMERC) cohort study
Summary
An elevated serum triglyceride level is a risk factor for developing cardiovascular disease. A number of studies have demonstrated a positive association between psychological stress and serum triglyceride levels. There is limited evidence regarding the impact of stressful life events (SLEs) on the serum triglyceride levels among the healthy population. We evaluated the independent association between stressful life events (SLEs) and serum triglyceride levels in a middle-aged t Korean population. The Korean version of the Life Experience Survey ea questionnaire was used to measure the presence and positive/negative impact of SLEs. ah Hypertriglyceridemia was defined as a fasting serum triglyceride level of ≥ 150 mg/dL. Even after adjusting for potential confounders, the serum triglyceride level was significantly associated with the total number of SLEs in men (3.333 mg/dL per event; p= 0.001), but not in women (0.451 mg/dL per event, p= 0.338). Hypertriglyceridemia was associated with having four or more positively affecting SLEs (OR= 2.57; 95% CI= 1.02 to 6.46) and negatively affecting SLEs (OR= 1.99; 95% CI= 1.16 to 3.41) in men
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