Abstract
Background: HBS is a quantitative liver function test and is used to assess liver function in patients scheduled for major liver resection. Normally it is performed after a 4 hours fast which corresponds with the resting liver function. Knowledge of the stimulated liver function could be of interest for optimal patient selection since the total liver function (TLF) might be underestimated in fasting patients. We aim to investigate the hepatic functional reserve capacity by assessing the change in TLF after stimulation with a fatty food challenge. Methods: Healthy volunteers (n=12) aged 50-60 years underwent sequential HBS with 100 MBq 99mTc-mebrofenin. The first scan was performed after an overnight fast, the second scan after an overnight fast followed by the administration of 250 mL full fat chocolate-milk prior to the scan. Hepatic 99mTc-mebrofenin uptake rate was calculated as an increase of 99mTc-mebrofenin uptake over a time period of 150 s. TLF was represented by the 99mTc-mebrofenin uptake rate as a percentage of the injected dose per minute (%/min). Results: TLF with and without a food challenge was 21,45 ± 3.01 %/min and 25,00 ± 4,26 %/min, respectively. There was a significant increase in the 99mTc-mebrofenin uptake rate after a fatty food challenge; i.e. 3.55 ± 2.51 %/min, 95% CI [2.10 – 5.00], P < 0.0001. Conclusion: TLF increased after administration of a fatty food challenge which may reflect hepatic functional reserve capacity. Future studies should determine which factors account for this difference.
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