Stress response in vertebra surgery by total intravenous and inhalation anaesthesia.

Abstract

We compared inhalational and total intravenous anaesthesia about haemodynamic stability and oxidative stress response in vertebral surgery. Fifty-nine elective vertebral surgery patients were randomly divided into propofol (Group P) and desflurane (Group D) groups. Intraoperative haemodynamic parameters, preoperative and post-operative native thiol, total thiol, disulfide, C-reactive protein (CRP), albumin, cortisol and catalase levels were studied. Post-operative native thiol and total thiol values in Group P were higher (P=.044 and P=.031). Post-operative albumin value in Group P was lower than the preoperative value (P<.001). The post-operative CRP and albumin values in Group D were lower than the preoperative value. The cortisol value was high (P=.03, P<.001 and P<.001). The post-operative albumin value in Group P was higher (P=.03). There is a positive correlation between CRP and disulfide values (P=.017), between albumin and native thiol values (P<.001), between total thiol value (P<.001), between the cortisol value and the disulfide/native thiol value (P=.002) and between native/total thiol value (P=.003) and a negative correlation between disulfide/native thiol value (P=.005), between disulfide/total thiol value (P=.003) and between the native/total thiol value (P=.001). Dynamic thiol/disulfide haemostasis reflects oxidative stress. Propofol positively contributes to oxidative stress in elective vertebral surgery.