Abstract
Aging is a physiological process that may develop long without manifestations of comorbidities. In the meantime a high proportion of elderly people very often experience limitations in daily life due to impairments in memory and other cognitive functions. Non-cognitive neuropsychiatric disorders, most commonly stress-related anxiety disorders, are a major contribution to maladaptation in these patients. The present studies of the neurobiology of aging enable one to decipher not only the mechanisms that underlie the physiology of brain aging, but also the factors that influence cognitive aging and aggravate the manifestations of cognitive dysfunction and neurodegenerative disease. The process of brain aging is known to presume the long-term preservation of functional neuroplasticity that is greatly influenced by different lifestyle factors, such as daily social and physical activities, the pattern and amount of food taken, cognitive activity, and stressful life events. These lifestyle factors are supposedly a potent tool to maintain physiological brain aging and a delayed cognitive diminution in elderly people. At the same time, studies of the possibility of pharmacologically correcting age-related (both cognitive and non-cognitive) impairments are promising to improve everyday function in elderly people.
Highlights
Старение – это физиологический процесс, который может длительно развиваться без манифестации сопутствующих заболеваний
The present studies of the neurobiology of aging enable one to decipher the mechanisms that underlie the physiology of brain aging, and the factors that influence cognitive aging and aggravate the manifestations of cognitive dysfunction and neurodegenerative disease
The process of brain aging is known to presume the long-term preservation of functional neuroplasticity that is greatly influenced by different lifestyle factors, such as daily social and physical activities, the pattern and amount of food taken, cognitive activity, and stressful life events
Summary
Старение – это физиологический процесс, который может длительно развиваться без манифестации сопутствующих заболеваний. Предполагается, что эти факторы образа жизни являются мощным инструментом поддержания физиологического старения мозга и отсроченного когнитивного снижения у пожилых людей. Предполагается, что среди лиц с УКН, сочетающимися с тревожными расстройствами, относительный риск развития БА более чем в 2 раза выше по сравнению с лицами без тревоги.
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