Abstract
IntroductionHelicobacter pylori infection is a major cause of gastric ulcers, and Helicobacter pylori eradication drastically reduces ulcer recurrence. It has been reported, however, that severe physical stress is closely associated with gastric ulceration even in Helicobacter pylori -negative patients.Case presentationWe report the cases of a 47-year-old Japanese man and a 69-year-old Japanese man who developed psychological stress-induced hemorrhagic gastric ulcers, in both of whom Helicobacter pylori had been successfully eradicated.ConclusionOur cases strongly suggest that not only physical but also psychological stress is still an important pathogenic factor for peptic ulceration and accordingly that physicians should pay attention to the possible presence of psychological stress in the management of patients with peptic ulcers.
Highlights
Helicobacter pylori infection is a major cause of gastric ulcers, and Helicobacter pylori eradication drastically reduces ulcer recurrence
It is well-documented, that Helicobacter pylori (Hp) infection is a major cause of peptic ulcers and that Hp eradication drastically reduces ulcer recurrence, thereby understating or even excluding the importance of stress in ulcer formation
We report the cases of two patients with psychological stress-induced hemorrhagic gastric ulcers in whom Hp had been successfully eradicated
Summary
Our case reports suggest that psychological stress is still an important clinical factor for peptic ulceration. 8. Schilling D, Haisch G, Sloot N, Jakobs R, Saggau W, Riemann JF: Low seroprevalence of Helicobacter pylori infection in patients with stress ulcer bleeding: a prospective evaluation of patients on a cardiosurgical intensive care unit. Robert R, Gissot V, Pierrot M, Laksiri L, Mercier E, Prat G, Villers D, Vincent JF, Hira M, Vignon P, Charlot P, Burucoa C: Helicobacter pylori infection is not associated with an increased hemorrhagic risk in patients in the intensive care unit. Doi:10.1186/1752-1947-5-252 Cite this article as: Moriya et al.: Stress-induced hemorrhagic gastric ulcer after successful Helicobacter pylori eradication: two case reports. Competing interests The authors declare that they have no competing interests
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