Abstract
The skin is a metabolically active organ with vital functions, such as protection and homeostasis, which are threatened by any disturbance in the structural and functional integrity of the skin. To protect against stress, it has evolved a local neuroendocrine system, which utilizes common ‘stress’ peptides and receptors. Corticotropin-releasing hormone (CRH) is a 41-amino acid polypeptide that plays a major role in coordinating autonomic, cardiovascular, endocrine and behavioural responses to stress. CRH and the related urocortin peptides exert their actions by activating two different families of receptors, CRH-R1 and CRH-R2, which have a high degree of sequence homology and are expressed as multiple protein isoforms generated by differential exon splicing. The skin expresses CRH, urocortin and multiple CRH receptor subtypes.
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