Abstract
Stress and pluripotency.
Highlights
Vacanti and colleagues recently reported the generation of mouse cells exhibiting pluri/totipotency by stress treatment, and showed that these cells can give rise to chimeras and clonal adults (Obokata et al, 2014a,b)
It is notable that stress-activated forkhead boxO 1 (FoxO1) has binding sites on the promoters of both Oct4 and Nanog in embryonic stem cells (ESC), and FoxO1 is known to be essential for maintenance of pluripotency of ESC (Zhang et al, 2011)
Stress could potentially reduce the activity of the nucleosome remodeling and deacetylation (NuRD) repressor complex (Opsahl et al, 2010) which acts in attenuating the downstream targets the reprogramming factors (Luo et al, 2013) promoting efficiency of reprogramming
Summary
Vacanti and colleagues recently reported the generation of mouse cells exhibiting pluri/totipotency by stress treatment, and showed that these cells can give rise to chimeras and clonal adults (Obokata et al, 2014a,b). How could stress alone result in induced pluripotency, indicated at the first instance by the formation of Oct4 expressing colonies?
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