Abstract
Objective To examine the histopathological effects of diabetes on spermatogenesis and to detect the proliferation of germ cells with proliferative cell nuclear antigen (PCNA). Design Controlled experimental study. Setting The animal laboratory of the Experimental Surgery Center of Ege University, Izmir, Turkey. Animal(s) Ten nondiabetic (control) and 20 diabetic adult male albino rats. Intervention(s) The rats were IP injected with 40 mg/kg streptozotocin for 5 days to create a diabetic condition that was confirmed by testing blood glucose levels 5–7 days after the first injection. Main outcome measure(s) Mean testicular diameter, mean semniferous tubuli diameter (MSTD), and PCNA index. Result(s) Six weeks after the streptozotocin injection, both the mean testicular and the seminiferous tubuli diameters were significantly decreased in diabetic rats compared with the control group. Conclusion(s) The effects of diabetes on spermatogenesis can be clearly detected as a decrease in testicular diameter, MSTD, and PCNA index.
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