Abstract
Three months after single injection of streptozotocin (50.0 mg/kg, i.p.), average activities of superoxide dismutase (SOD) and glutathione reductase (GTR) in tissues of the retina of Wistar rats were lower by 47.5 and 42.2%, respectively, while the content of malondialdehyde (MDA) was about 330% of the norm. Recording of electroretinogram (ERG) showed that the amplitude of wave a in these animals was significantly lower (by 57.3%), while the latencies of waves a and b exceeded normal values by 27.5 and 11.8 %, respectively (P < 0.05). After injections of δ sleep-inducing peptide (δSIP, 0.05 mg/kg, i.p., once every three days for two months), SOD and GTR activities did not differ significantly from normal values, while the MDA level was higher by 53.7% (P < 0.05). The mean amplitude of ERG wave a demonstrated no considerable difference from the norm; at the same time, the latencies of waves a and b still exceeded normal values by 13.2 and 10.4 %, respectively. Therefore, negative changes in the functional state of the retina observed because of the development of diabetic retinopathy undergo noticeable moderation under the influence of δSIP.
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