Abstract
Biofilms formed by methicillin-resistant S. aureus (MRSA) are among the most frequent causes of biomedical device-related infection, which are difficult to treat and are often persistent and recurrent. Thus, new and effective antibiofilm agents are urgently needed. In this article, we review the most relevant literature of the recent years reporting on promising anti-MRSA biofilm agents derived from the genus Streptomyces bacteria, and discuss the potential contribution of these newly reported antibiofilm compounds to the current strategies in preventing biofilm formation and eradicating pre-existing biofilms of the clinically important pathogen MRSA. Many efforts are evidenced to address biofilm-related infections, and some novel strategies have been developed and demonstrated encouraging results in preclinical studies. Nevertheless, more in vivo studies with appropriate biofilm models and well-designed multicenter clinical trials are needed to assess the prospects of these strategies.
Highlights
Methicillin-resistant Staphylococcus aureus (MRSA) is a harmful human pathogen responsible for severe morbidity and mortality worldwide [1]
The ability to form biofilms that protect the bacterial cells from host defenses and antibiotic therapy has contributed to the majority of chronic staphylococcal infections, especially those associated with indwelling medical devices
There is no approved drug that acts against MRSA biofilms in clinical trials, indicating there is an urgent need for alternative strategies
Summary
Methicillin-resistant Staphylococcus aureus (MRSA) is a harmful human pathogen responsible for severe morbidity and mortality worldwide [1]. To improve the current strategies of biofilm inhibition, the aim of the present review is to highlight that the microbial metabolites, from the genus Streptomyces, are treasure troves for anti-MRSA biofilm agents, which have the potential for the development of effective and safe therapeutic strategies for MRSA biofilm-associated infections. These anti-MRSA biofilm agents can interfere with different stages of the biofilm developmental process, including to inhibit biofilm formation, mainly via interfering with bacterial adhesion, or disrupt preformed biofilms via destroying the matrix architecture or modulating the complex regulatory systems involved in biofilm formation
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
