Abstract
Observations<sup>1</sup>are available which show that as little as from 0.0001 to 0.001 mg. of nitrogen of Streptococcus scarlatinae is capable of producing characteristic skin reactions in susceptible patients. Other studies<sup>2</sup>have indicated that equivalent quantities of nucleoprotein derived from the hemolytic streptococcus may induce fever and malaise in patients with rheumatic fever. Some workers<sup>3</sup>hold that untoward constitutional reactions sometimes follow the intravenous injection of similar quantities of nucleoprotein in patients with subacute glomerular nephritis. Derick<sup>4</sup>has recently reported clinical improvement in patients with subacute hemorrhagic nephritis following repeated intravenous injections of a hemolytic streptococcus nucleoprotein. This communication is presented in order that the clinician may better appreciate the relatively small number of bacteria required to produce these reactions. A virulent strain of Streptococcus scarlatinae was grown for forty-eight hours in forty 1.5 liter portions of beef infusion broth containing 1 per cent of peptone
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