Abstract

Current UK practice demonstrates that weaning from mechanical ventilation (MV) is an ad-hoc process, where weaning is not valued and there is a paucity of research related to weaning compared with North America and other European countries. Evidence exists outside the United Kingdom that proactive approaches to weaning yield benefits to service and coordination form a dedicated, experienced practitioner within a systematic framework generates positive outcomes. The Surrey Wide Critical Care Network (SWCCN) comprises four district general hospitals with a total of 30 level-3 critical care beds. A weaning audit was undertaken by the SWCCN Nurse Consultant across all four ICUs over a 3-month period in 2003. The audit demonstrated that the process of weaning was often inconsistent and at times haphazard, especially in relation to those patients who have difficulty in weaning from MV. This often led to an unnecessary increase in ICU length of stay (LOS). The audit also established that patients weaning from MV can be identified into three groups: (1) those patients who will wean from MV within 24–72 hours; (2) those patients who will wean from MV within 3–21 days; and (3) those patients who will have a prolonged stay in ICU and a complex weaning process greater than 21 days. In order to streamline and coordinate the whole weaning process and effectively manage the three groups of weaning patients across the SWCCN, a systematic evidence-based framework with three distinct pathways was developed and implemented within in all four ICUs by the Network Nurse Consultant (Fig. ​(Fig.11). Figure 1 Weaning pathway. Following 1 year of implementation the framework was audited and demonstrated the following: • The process of weaning all three patient groups within all four ICUs was much more systematic and consistent. • A reduction in ITU LOS in patient groups 1 and 2. • Quicker identification and placement onto the rehabilitation pathway of those patients who would require a prolonged ITU stay and have complex weaning problems. Their management and care was much more coordinated. • Symbiosis of ventilation care bundle and weaning framework. • Identification for the need of a specialist regional weaning unit.

Highlights

  • Tight blood glucose (BG) control has been shown to videos of the alveolar dynamics

  • 1Royal Brompton Hospital, London, UK; 2Medical University Graz, observation from mechanical deformation due to the tip of the Austria; 3Charles University Hospital, Prague, Czech Republic; endoscope we developed a flushing catheter that continuously

  • Taurocholic acid into the pancreatic duct. This allowed us to separate and to determine the specific role of pancreatic blood vs Introduction In the frame of protective lung ventilation, alveolar normal blood on the expression of injury evidenced during isolated biomechanics become more and more the focus of scientific lung reperfusion

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Summary

Introduction

Tight blood glucose (BG) control has been shown to videos of the alveolar dynamics. The thorax remains intact.decrease morbidity and mortality in critically ill patients [1] but is Results Figure 1 shows a tissue area after lavage of 0.8 mm difficult to achieve using standard insulin infusion protocols. Results Patient characteristics (mean ± SD): age 57.4 ± 15.4 years, 28 female, 52 male, APACHE II score 28.2 ± 6.6; number of organ failures 4.0 ± 1.12; preceding ICU period 8.5 ± 9.3 days; continuous sedation with midazolam 31.2 ± 34.2 mg/hour, fentanyl 0.12 ± 0.08 mg/hour, propofol 45.6 ± 105.2 mg/hour; sedation assessment according to RS 5.65 ± 0.63, CPS 5.15 ± 1.67, CKS 0.65 ± 0.69, CS 9.34 ± 2.13 und LSS 1.78 ± 1.69, RASS –4.50 ± 1.27, FiO2 0.52 ± 0.17, PEEP 8.2 ± 2.4 cmH2O, ventilatory frequency 20.5 ± 4.8/min, pressure control 16.8 ± 4.4 cmH2O, tidal volume 540 ± 115 ml, TVV 2525.6 ± 11,366 ml (minimum 1.52; maximum 91,586). We hypothesized that S100β levels correlate with this tumor’s preoperative characteristics and with perioperative neurological injury despite its supratentorial location and non-neural origin

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