Abstract
Three new dinuclear arene ruthenium metalla-clips of the general formula [(p-cymene)2Ru2Cl2(μ-L)] have been prepared from [(p-cymene)2Ru2Cl2(μ-Cl)2] and H2L organic linkers (H2La = diethyl-1,2-diazenedicarboxylate, H2Lb = N,N′-bis(2-hydroxyethyl)oxamide, H2Lc = N,N′-bis{2-(2-hydroxyethoxy)ethyl}ethanediamide). The bis-chelating bridging-linkers possess two functional groups that can be synthetically modified for physico-chemical optimizations. Reaction of these three dinuclear metalla-clips with 4,4′-bipyridine, 1,2-bis(4-pyridyl)ethylene, and 4,4′-azopyridine affords, in the presence of AgCF3SO3, nine tetracationic tetranuclear metalla-rectangles. Similarly, the tridentate ligands 2,4,6-tris(4-pyridyl)-1,3,5-triazine and 1,3,5-tris{2-(4-pyridyl)vinyl}benzene were used to generate six hexacationic hexanuclear metalla-prisms. All metalla-assemblies and the dinuclear complexes were evaluated as anticancer agents against cancerous (A2780) and noncancerous (HEK293) cell lines, showing an excellent selectivity...
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