Strategy of Metabolic Engineering Microorganism for High Yield Amino Acids

Abstract

Amino acids,which play the irreplaceable role in maintaining the body's normal physiology as a kind of nutrient substances,are usually used as additives in food,pharmaceuticals,and cosmetics. Production of amino acids mainly relies on microbial fermentation. However,high yield amino acid strain by selection hinders the large-scale industrial production. Application of metabolic engineering has become a hot spot of research in microbial metabolism network and genetically modification for screening high yield amino acid strain with the development of metabolic engineering strategy and technology in molecular breeding. The characteristic of C.glutamicum metabolism network and metabolic engineering strategy in molecular breeding of C. glutamicumproducing amino acids are introduced.