Abstract
Treatment of cancer with vaccines is an attractive prospect, but few tumors express suitable target antigens. Idiotypic determinants of the immunoglobulins expressed on the surface of B-cell lymphomas are tumor-specific antigens (TSAs), which can be targeted by immunotherapy [1–4]. Numerous investigators have reported that idiotypic determinants on the variable region of Ig molecules are capable of eliciting idiotype (Id)-specific responses in xenogenic, syngenic, and autologous immunization systems.
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